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Nuclear Receptor Signaling Atlas
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TBL1XR1
Overview
Synonyms
8030499H02Rik ; A630076E03Rik ; AW539987 ; C21 ; C230089I12Rik ; DC42 ; F-box-like/WD repeat protein TBL1XR1 ; F-box-like/WD repeat-containing protein TBL1XR1 ; HOS15 ; IRA1 ; Ira1 ; K8K14.4 ; K8K14_4 ; RGD1560053 ; TBL1-related protein 1 ; TBL1XR1 ; TBLR1 ; Tbl1xr1 ; high expression of osmotically responsive genes 15 ; nuclear receptor co-repressor/HDAC3 complex subunit ; nuclear receptor corepressor/HDAC3 complex subunit TBLR1 ; transducin (beta)-like 1X-linked receptor 1 ; transducin beta-like 1X-related protein 1
NURSA Name
Nuclear receptor co-repressor/HDAC3 complex subunit TBLR1
Official Symbol
TBL1XR1
No records found.
Description
TBLR1 and its related protein TBL1 are WD-40 repeat proteins that have been identified as members of a SMRT complex and were originally shown to be corepressors of unliganded thyroid receptor (TR).
Original References:
Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA and Shiekhattar R (2000) A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes Dev. 14 1048-57 View Abstract | View PubMed
Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J and Wong J (2003) Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J. 22 1336-46 View Abstract | View PubMed
Bassi MT, Ramesar RS, Caciotti B, Winship IM, De Grandi A, Riboni M, Townes PL, Beighton P, Ballabio A and Borsani G (1999) X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats. Am. J. Hum. Genet. 64 1604-16 View Abstract | View PubMed
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