Breast cancer nuclear receptor-binding auxiliary protein
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Members of the Dbl family of oncoproteins are involved in the regulation of cell growth and other cellular functions. Brx is a Dbl family member that was isolated in a screen for interacting partners of the retinoid X receptor, a member of the nuclear receptor (NR) transcription factor superfamily. It was shown to enhance transactivation by estrogen receptor alpha (ERalpha), another member of the NR superfamily.
Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, Pagliai K, Gray K, Gutkind S and Segars J (1998) Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. Oncogene
Find genes regulated by this molecule using Transcriptomine, a tool created by NURSA for mining tissue-specific NR, NR ligand, and coregulator transcriptomes based on published genome wide transcriptional profiling experiments in the field of nuclear receptor signaling.
Note: This link will take you to a Transcriptomine query page. For website performance, only results containing 500 fold changes or fewer can be viewed in your browser. If these preset parameters retrieve more than 500 fold changes, you will have the option to download the results as an Excel file or adjust the query parameters (e.g. fold change size, tissue/cell line) to reduce the number of results so that you can view them in your web browser.