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Nuclear Receptor Signaling Atlas
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AKAP13
Overview
Synonyms
1700026G02Rik ; 5730522G15Rik ; 5830460E08Rik ; A-kinase anchor protein 13 ; A-kinase anchoring protein ; AKAP-13 ; AKAP-Lbc ; AKAP13 ; ARHGEF13 ; Akap13 ; BRX ; HA-3 ; Ht31 ; LBC ; LBC oncogene ; PRKA13 ; PROTO-LB ; PROTO-LBC ; breast cancer nuclear receptor-binding auxiliary protein ; c-lbc ; fi40d09 ; guanine nucleotide exchange factor Lbc ; human thyroid-anchoring protein 31 ; lymphoid blast crisis oncogene ; non-oncogenic Rho GTPase-specific GTP exchange factor more...
Synonyms
1700026G02Rik; 5730522G15Rik; 5830460E08Rik; A-kinase anchor protein 13; A-kinase anchoring protein; AKAP-13; AKAP-Lbc; AKAP13; ARHGEF13; Akap13; BRX; HA-3; Ht31; LBC; LBC oncogene; PRKA13; PROTO-LB; PROTO-LBC; breast cancer nuclear receptor-binding auxiliary protein; c-lbc; fi40d09; guanine nucleotide exchange factor Lbc; human thyroid-anchoring protein 31; lymphoid blast crisis oncogene; non-oncogenic Rho GTPase-specific GTP exchange factor; p47; protein kinase A anchoring protein Rt31; protein kinase A-anchoring protein 13; si:dkey-187e18.1; type II cAMP-dependent protein kinase anchoring protein Ht31; wu:fi40d09
NURSA Name
Breast cancer nuclear receptor-binding auxiliary protein
Official Symbol
AKAP13
No records found.
Description
Members of the Dbl family of oncoproteins are involved in the regulation of cell growth and other cellular functions. Brx is a Dbl family member that was isolated in a screen for interacting partners of the retinoid X receptor, a member of the nuclear receptor (NR) transcription factor superfamily. It was shown to enhance transactivation by estrogen receptor alpha (ERalpha), another member of the NR superfamily.
Original References:
Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, Pagliai K, Gray K, Gutkind S and Segars J (1998) Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. Oncogene 16 2513-26 View Abstract | View PubMed
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