Ankyrin repeats containing cofactors (ANCOs) interact with the p160 coactivators. ANCO-1 was identified from a yeast two-hybrid screen as a RAC3-interacting protein. ANCOs inhibit ligand-dependent transactivation by both steroid and nonsteroid nuclear receptors.
Zhang A, Yeung PL, Li CW, Tsai SC, Dinh GK, Wu X, Li H and Chen JD (2004) Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators. J. Biol. Chem.
Find genes regulated by this molecule using Transcriptomine, a tool created by NURSA for mining tissue-specific NR, NR ligand, and coregulator transcriptomes based on published genome wide transcriptional profiling experiments in the field of nuclear receptor signaling.
Note: This link will take you to a Transcriptomine query page. For website performance, only results containing 500 fold changes or fewer can be viewed in your browser. If these preset parameters retrieve more than 500 fold changes, you will have the option to download the results as an Excel file or adjust the query parameters (e.g. fold change size, tissue/cell line) to reduce the number of results so that you can view them in your web browser.