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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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MED14
Overview
Synonyms
9930001L01Rik ; ARC150 ; AU041628 ; CG12031 ; CG12031-PA ; CG12031-PB ; CRSP complex subunit 2 ; CRSP150 ; CRSP2 ; CSRP ; CXorf4 ; Crsp2 ; DRIP150 ; Dmel\CG12031 ; ENSMUSG00000073278 ; EXLM1 ; Gm641 ; MED14 ; MED14-PA ; MED14-PB ; Med14 ; ORF1 ; RGD1560170 ; RGR1 ; RGR1 homolog more...
Synonyms
9930001L01Rik; ARC150; AU041628; CG12031; CG12031-PA; CG12031-PB; CRSP complex subunit 2; CRSP150; CRSP2; CSRP; CXorf4; Crsp2; DRIP150; Dmel\CG12031; ENSMUSG00000073278; EXLM1; Gm641; MED14; MED14-PA; MED14-PB; Med14; ORF1; RGD1560170; RGR1; RGR1 homolog; TRAP170; Trap170; activator-recruited cofactor 150 kDa component; cofactor required for Sp1 transcriptional activation subunit 2 (150 kDa); cofactor required for Sp1 transcriptional activation, subunit 2; cofactor required for Sp1 transcriptional activation, subunit 2 (150kD); cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa; crsp150; crsp2; dTRAP170; hRGR1; human homolog of yeast RGR1; med14; mediator complex subunit 14; mediator of RNA polymerase II transcription subunit 14; p160; thyroid hormone receptor-associated protein complex 170 kDa component; thyroid hormone receptor-associated protein complex component TRAP170; transcriptional co-activator CRSP150; trap170; vitamin D receptor-interacting protein complex component DRIP150; vitamin D3 receptor-interacting protein complex 150 kDa component; wu:fd21c05; wu:fk28h11
NURSA Name
Vitamin D receptor-interacting protein complex component 150
Official Symbol
MED14
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Description
The broad-specificity DRIP/TRAP coregulator complex mediates transcriptional activation by members of the nuclear receptor superfamily and other transcription factors. The DRIP150 subunit has been individually characterized as a nuclear receptor coactivator.
Original References:
Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J and Roeder RG (1999) A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol. Cell 3 97-108 View Abstract | View PubMed
Lee JW, Choi HS, Gyuris J, Brent R and Moore DD (1995) Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Mol. Endocrinol. 9 243-54 View Abstract | View PubMed
Wang Q, Sharma D, Ren Y and Fondell JD (2002) A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. J. Biol. Chem. 21 42852-8 View Abstract | View PubMed
Fondell JD, Ge H and Roeder RG (1996) Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc. Natl. Acad. Sci. U.S.A. 93 8329-33 View Abstract | View PubMed
Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W and Tjian R (1999) Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature 398 828-32 View Abstract | View PubMed
Ortholog
Gene
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Protein-Protein Interactions
Targeting miRNAs
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