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Nuclear Receptor Signaling Atlas
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ANP32A
Overview
Synonyms
ANP32A ; ANP32D ; Acid nuclear phosphoprotein 32 (leucine rich) ; Anp32 ; Anp32a ; C15orf1 ; CG5784 ; CG5784-PA ; CG5784-PB ; CG5784-PC ; CG5784-PD ; CT18148 ; CT42180 ; Dmel\CG5784 ; HPPCn ; I1PP2A ; LANP ; MAPM ; Mapmodulin ; Mapmodulin-PA ; Mapmodulin-PB ; Mapmodulin-PC ; Mapmodulin-PD ; PHAP1 ; PHAPI more...
Synonyms
ANP32A; ANP32D; Acid nuclear phosphoprotein 32 (leucine rich); Anp32; Anp32a; C15orf1; CG5784; CG5784-PA; CG5784-PB; CG5784-PC; CG5784-PD; CT18148; CT42180; Dmel\CG5784; HPPCn; I1PP2A; LANP; MAPM; Mapmodulin; Mapmodulin-PA; Mapmodulin-PB; Mapmodulin-PC; Mapmodulin-PD; PHAP1; PHAPI; PP32; W91701; acidic (leucine-rich) nuclear phosphoprotein 32 family, member D; acidic leucine-rich nuclear phosphoprotein 32 family member A; acidic nuclear phosphoprotein 32; acidic nuclear phosphoprotein 32 family, member A; acidic nuclear phosphoprotein pp32; anon-EST:fe3A2; anon-fast-evolving-3A2; anp32a; cerebellar leucine rich acidic nuclear protein; hepatopoietin Cn; inhibitor-1 of protein phosphatase-2A; leucine-rich acidic nuclear protein; leucine-rich acidic nuclear protein LANP; mapmodulin; potent heat-stable protein phosphatase 2A inhibitor I1PP2A; pp32; putative HLA-DR-associated protein I; putative human HLA class II associated protein I; vacidic (leucine-rich) nuclear phosphoprotein 32 family, member A; wu:fj36e08; zgc:55516
NURSA Name
Phosphoprotein 32 Kda
Official Symbol
ANP32A
No records found.
Description
pp32 was found associated with ERα in MCF7 cells and and to enhance ER-ERE complex formation but to decrease ER-mediated transcription, possibly through pp32 ability to decrease acetylation of ERα and histones. pp32 was also reported to bind to TRβ, PR-B, PPARγ and AR. Howver, pp32 was reported to act as a coactivator for AR-mediated transcription and this activity is modulated by the retinoblastoma protein.
Original References:
Adegbola O and Pasternack GR (2005) A pp32-retinoblastoma protein complex modulates androgen receptor-mediated transcription and associates with components of the splicing machinery. Biochem. Biophys. Res. Commun. 78 702-8 View Abstract | View PubMed
Vaesen M, Barnikol-Watanabe S, Götz H, Awni LA, Cole T, Zimmermann B, Kratzin HD and Hilschmann N (1994) Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII. Biol. Chem. Hoppe-Seyler 119 113-26 View Abstract | View PubMed
Seo SB, McNamara P, Heo S, Turner A, Lane WS and Chakravarti D (2001) Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Cell 104 119-30 View Abstract | View PubMed
Loven MA, Davis RE, Curtis CD, Muster N, Yates JR and Nardulli AM (2004) A novel estrogen receptor alpha-associated protein alters receptor-deoxyribonucleic acid interactions and represses receptor-mediated transcription. Mol. Endocrinol. 18 2649-59 View Abstract | View PubMed
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