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Nuclear Receptor Signaling Atlas
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APPL1
Overview
Synonyms
2900057D21Rik ; 7330406P05Rik ; AI585782 ; AKT2 interactor ; APPL ; APPL1 ; AW209077 ; Appl1 ; BB022931 ; C88264 ; DCC-interacting protein 13-alpha ; DIP13 ; DIP13 alpha ; DIP13alpha ; RGD1309388 ; adapter protein containing PH domain, PTB domain and leucine zipper motif 1 ; adaptor protein APPL like ; adaptor protein containing pH domain, PTB domain and leucine zipper motif ; adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 ; appl1 ; dip13-alpha ; signaling adaptor protein DIP13alpha
NURSA Name
Adaptor protein containing pH domain, PTB domain and leucine zipper motif
Official Symbol
APPL1
No records found.
Description
APPL was initially identified as an Akt-interacting protein expressed in multiple human tissues and has been shown to act as a corepressor for the androgen receptor (AR).
Original References:
Yang L, Lin HK, Altuwaijri S, Xie S, Wang L and Chang C (2003) APPL suppresses androgen receptor transactivation via potentiating Akt activity. J. Biol. Chem. 22 16820-7 View Abstract | View PubMed
Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA and Testa JR (1999) Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 18 4891-8 View Abstract | View PubMed
Ortholog
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