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Nuclear Receptor Signaling Atlas
A research resource for the nuclear receptor signaling community
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PGR
Overview
Synonyms
9930019P03Rik ; BB114106 ; ENSMUSG00000074510 ; NR3C3 ; Nuclear receptor subfamily 3 group C member 3 ; PGR ; PR ; PR-A ; PR-B ; Pgr ; nuclear receptor subfamily 3 group C member 3
NURSA Name
Progesterone receptor
Official Symbol
PGR
No records found.
Description
The progesterone receptor (PR) is a progestin-activated steroid receptor member of the nuclear receptor superfamily of transcription factors. It plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior. PR is expressed at trace to low levels in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural), with peaks in the uterus and ovary, cerebellum, spinal cord and hypothalamus. PR dysfunction has been associated with cancer (ovarian cancer, breast cancer, endometrial cancer, and prostate cancer), metabolic disorders (progesterone resistance, obesity, and osteoporosis), cardiovascular defects (aortic aneurysm), neurological defects (migraine, vertigo) and reproductive conditions (endometriosis, infertility). Targeted deletion (knockout) of PR results in developmental, behavioral, reproductive and immune system phenotypes.
Original References:
Conneely OM, Sullivan WP, Toft DO, Birnbaumer M, Cook RG, Maxwell BL, Zarucki-Schulz T, Greene GL, Schrader WT and O'Malley BW (1986) Molecular cloning of the chicken progesterone receptor. Science 233 767-70 View Abstract | View PubMed
Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H and Chambon P (1990) Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 9 1603-14 View Abstract | View PubMed
Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F and Milgrom E (1987) Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA. Biochem. Biophys. Res. Commun. 143 740-8 View Abstract | View PubMed
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