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Nuclear Receptor Signaling Atlas
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NR2F1
Overview
Synonyms
COUP transcription factor 1 ; COUP transcription factor 1-A ; COUP transcription factor I ; COUP(VI) ; COUP-TF ; COUP-TF I ; COUP-TF1 ; COUP-TFI ; COUP-TFalpha-A ; COUPTFA ; COUPTFalpha-A ; EAR-3 ; EAR3 ; ERBAL3 ; Erbal3 ; LOC100859519 ; NR2F1 ; NR2F2 ; Nr2f1 ; SVP44 ; TCFCOUP1 ; TFCOUP1 ; Tcfcoup1 ; V-erbA-related protein 3 ; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 3 more...
Synonyms
COUP transcription factor 1; COUP transcription factor 1-A; COUP transcription factor I; COUP(VI); COUP-TF; COUP-TF I; COUP-TF1; COUP-TFI; COUP-TFalpha-A; COUPTFA; COUPTFalpha-A; EAR-3; EAR3; ERBAL3; Erbal3; LOC100859519; NR2F1; NR2F2; Nr2f1; SVP44; TCFCOUP1; TFCOUP1; Tcfcoup1; V-erbA-related protein 3; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 3; chicken ovalbumin upstream promoter-transcription factor; chicken ovalbumin upstream promoter-transcription factor I; couptf6; etID309751.5; fc10d05; nr2f1; nr2f1a; nuclear receptor subfamily 2 group F member 1; nuclear receptor subfamily 2 group F member 1-A; nuclear receptor subfamily 2, group F, member 1; seven-up related 44; steroid receptor homolog SVP 44; svp44; svp[44]; transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-a homolog-like 3); unc-55; wu:fc10d05; zCOUP-TFI; zSvp[44]
NURSA Name
Chicken ovalbumin upstream promoter transcription factor I
Official Symbol
NR2F1
No records found.
Description
COUP-TFI is a member of the COUP-TF orphan subfamily of the nuclear receptor superfamily of transcription factors. It has varied roles in the development of the peripheral nervous system, such as early regionalization of the neocortex, differentiation of subplate neurons and guidance of thalamocortical axons. COUP-TFI is expressed in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the cerebellum, corpus striatum, olfactory bulb, spinal cord, hypothalamus and vas deferens. Targeted deletion (knockout) of COUP-TFI results in defects in the formation of commissural projections in the forebrain due to impaired axonal growth, as well as defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization.
Original References:
Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K and Yamamoto T (1988) Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. Nucleic Acids Res. 16 11057-74 View Abstract | View PubMed
Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ and O'Malley BW (1989) COUP transcription factor is a member of the steroid receptor superfamily. Nature 84 163-6 View Abstract | View PubMed
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