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Nuclear Receptor Signaling Atlas
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NR2F6
Overview
Synonyms
AV090102 ; COUP transcription factor 3 ; COUP(II) ; COUP-TF3 ; COUPg ; EAR-2 ; EAR2 ; EAR2-A ; ERBA-related gene-2 ; ERBAL2 ; Erbal2 ; NR2F6 ; Nr2f6 ; V-erbA-related protein 2 ; V-erbA-related protein EAR-2 ; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 2 ; chicken ovalbumin upstream promoter transcription factor 2 ; couptf2 ; fc94g11 ; nr2f6a ; nuclear receptor V-erbA-related ; nuclear receptor subfamily 2 group F member 6 ; nuclear receptor subfamily 2, group F, member 6 ; orphan nuclear receptor EAR-2 ; ovalbumin upstream promoter gamma nuclear receptor rCOUPg more...
Synonyms
AV090102; COUP transcription factor 3; COUP(II); COUP-TF3; COUPg; EAR-2; EAR2; EAR2-A; ERBA-related gene-2; ERBAL2; Erbal2; NR2F6; Nr2f6; V-erbA-related protein 2; V-erbA-related protein EAR-2; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 2; chicken ovalbumin upstream promoter transcription factor 2; couptf2; fc94g11; nr2f6a; nuclear receptor V-erbA-related; nuclear receptor subfamily 2 group F member 6; nuclear receptor subfamily 2, group F, member 6; orphan nuclear receptor EAR-2; ovalbumin upstream promoter gamma nuclear receptor rCOUPg; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2; wu:fc94g11; zgc:77259
NURSA Name
V-erbA related protein
Official Symbol
NR2F6
No records found.
Description
EAR2 is a member of the COUP-TF orphan subfamily of the nuclear receptor superfamily of transcription factors. Its functions include negative regulation of renin gene transcription and neuronal development. EAR2 is expressed in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the colon, gall bladder, kidney and aorta. Targeted disruption (knockout) of the Ear2 in mice results in abnormal development of the locus coeruleus, which also impairs the functionality of the forebrain clock and affects nociception.
Original References:
Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K and Yamamoto T (1988) Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. Nucleic Acids Res. 16 11057-74 View Abstract | View PubMed
Ortholog
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