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Nuclear Receptor Signaling Atlas
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ESRRA
Overview
Synonyms
ERR-alpha ; ERR1 ; ERRa ; ERRalpha ; ESRL1 ; ESRRA ; ESTRRA ; Err1 ; Errra ; Esrra ; Estrra ; LOC722085 ; NR3B1 ; Nr3b1 ; Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1) ; err1 ; erra ; erralpha ; esrra ; esrral ; estrogen receptor related 1 ; estrogen receptor-like 1 ; estrogen-related nuclear receptor alpha ; estrogen-related receptor 1 ; estrogen-related receptor alpha more...
Synonyms
ERR-alpha; ERR1; ERRa; ERRalpha; ESRL1; ESRRA; ESTRRA; Err1; Errra; Esrra; Estrra; LOC722085; NR3B1; Nr3b1; Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1); err1; erra; erralpha; esrra; esrral; estrogen receptor related 1; estrogen receptor-like 1; estrogen-related nuclear receptor alpha; estrogen-related receptor 1; estrogen-related receptor alpha; estrogen-related receptor, alpha; nuclear receptor subfamily 3 group B member 1; orphan nuclear receptor; steroid hormone receptor ERR1
NURSA Name
Estrogen-related receptor α
Official Symbol
ESRRA
No records found.
Description
ERR-α is a member of the ERR orphan subfamily of the nuclear receptor superfamily of transcription factors. While it is structurally homologous to estrogen receptors and binds estrogen response elements, it is not activated by estrogens. It functions as a metabolic regulator by modulating the expression of enzymes involved in adipogenesis, energy metabolism, and lipid, eicosanoid, and steroid synthesis. ERRα is expressed robustly in tissues in all major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural) with particularly high levels in the olfactory bulb, jejunum, ileum, kidney, brown adipose tissue, heart and skeletal muscle. ERRα dysfunction has been associated with bone density and type II diabetes. Targeted deletion (knockout) of ERRα results in defects in reduced fat mass.
Original References:
Giguère V, Yang N, Segui P and Evans RM (1988) Identification of a new class of steroid hormone receptors. Nature 75 91-4 View Abstract | View PubMed
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