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Nuclear Receptor Signaling Atlas
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ESR2
Overview
Synonyms
CERB ; ER beta ; ER-BETA ; ER-beta ; ERB ; ERBETA ; ER[b] ; ER[b]1 ; ERbeta ; ERbeta-A ; ESR-BETA ; ESR2 ; ESRB ; ESTRB ; Erb ; Erb2 ; Esr2 ; Estrb ; NR3A2 ; NR3A2-A ; esr2b ; estrogen nuclear receptor beta variant a ; estrogen nuclear receptor beta variant b ; estrogen receptor 2 beta ; estrogen receptor beta more...
Synonyms
CERB; ER beta; ER-BETA; ER-beta; ERB; ERBETA; ER[b]; ER[b]1; ERbeta; ERbeta-A; ESR-BETA; ESR2; ESRB; ESTRB; Erb; Erb2; Esr2; Estrb; NR3A2; NR3A2-A; esr2b; estrogen nuclear receptor beta variant a; estrogen nuclear receptor beta variant b; estrogen receptor 2 beta; estrogen receptor beta; estrogen receptor beta 4; estrogen receptor beta1; nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; zfER-beta1; zfER[b]1
NURSA Name
Estrogen receptor β
Official Symbol
ESR2
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Description
Estrogen receptor-β is a 17β-estradiol-activated steroid receptor member of the nuclear receptor superfamily of transcription factors. Roles for ER-β in the reproductive and cardiovascular systems have been reported, and ER-β has been postulated to act primarily as a modulator of ER-α function. ERβ has a restricted expression pattern, with low levels in the central nervous system (CNS), colon, lung and reproductive system (epididymis, prostate), and comparatively high levels in the ovary. ER-β dysfunction is associated with cancer (breast cancer, colorectal cancer, endometrial cancer, prostate cancer, uterine cancer), cardiovascular defects (coronary atherosclerosis, elevated arterial blood pressure, elevated triacylglycerol lipoprotein levels, hypertension, deep vein thrombosis), metabolic defects (bone mineral density, osteoporosis), neurological defects (Alzheimer's disease, Parkinson's disease), psychiatric conditions (anorexia nervosa, bulimia, major depressive disorder) and reproductive disorders (endometriosis, menstrual disorders and preeclampsia). Targeted deletion (knockout) of ERβ results in defects in the cardiovascular system, the hearing & vestibular system, homeostasis and metabolism, the musculoskeletal system, the central nervous system (CNS) and the renal/urinary system.
Original References:
Mosselman S, Polman J and Dijkema R (1996) ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett. 392 49-53 View Abstract | View PubMed
Moore JT, McKee DD, Slentz-Kesler K, Moore LB, Jones SA, Horne EL, Su JL, Kliewer SA, Lehmann JM and Willson TM (1998) Cloning and characterization of human estrogen receptor beta isoforms. Biochem. Biophys. Res. Commun. 247 75-8 View Abstract | View PubMed
Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S and Gustafsson JA (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. U.S.A. 93 5925-30 View Abstract | View PubMed
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